LCaos Newsletter - Issues no . 2 & 3

Welcome!

 
Dear Readers,
 
Welcome to the second & third issues of the LCaos Newsletter.  This newsletter is intended to bring to you the latest news coming from our FP7 LCaos consortium activities and achievements.
 
The opening section is a new-added section, Upcoming Events, which announces happenings, activities or actions organized or related to the LCaos project. The following section, LCaos Activities & Achievements, describes the Board Meeting that took place on May 25, 2012 in Nuremberg, Germany and the General Assembly Meeting that took place on September 5-6, 2012 in Innsbruck, Austria. The LCaos Technical Developments section contains information about the technical developments and current work status, as well as some major outcomes and plans for the future. The next section, LCaos Events, Publications and Awards advertises relevant workshops and conferences, and a list of publications and awards resulting from the project’s activities. Finally, the LCaos Exchanges and Position Openings section is dedicated to exchange opportunities and position openings. This is the place for each partner to advertise any M.Sc, Ph.D or post-doctoral open position, or any opportunities and exchanges for visiting researchers.
 
We really hope you will enjoy reading this newsletter! In the same time, we highly encourage all our readers to send us feedback and comments. We would also be pleased to receive more pictures and contributions from all our project partners!
 
Wishing you success in your research and lectures!
 
Prof. Hossam Haick and Dr. Silvia Birsan
LCaos Newsletter


LCaos Upcoming Events

The first LCaos workshop and the ISOCS training sessions are approaching: June 2013!

The first Workshop on Lung Cancer Artificial Olfactory System - LCaos - will be organized on June 13-14, 2013, in Saarbrücken/Wallerfangen, Germany.

 
The LCaos workshop is jointly organized with the Breath Analysis Summit 2013 (June 9-12, 2013) and the ISOCS Short Course on Chemical Sensors for Breath Analysis (June 14, 2013). All events will take place at the same location. The LCaos workshop aims to bring the latest updates on volatile markers for early diagnosis and classification of lung cancer. Additionally, the workshop aims to being the latest updates on chemical sensors and nanoarrays for the diagnosis of lung cancer via volatile markers. The LCaos workshop will bring together scientists, engineers, clinicians, industry executives, and entrepreneurs to discuss key trends, future directions, and technologies available for chemical sensors and nanoarrays for lung cancer diagnosis via volatile markers.
 
Structure:
Oral and poster contributions are welcome. Abstracts have to be composed following the provided template. Abstracts have to be sent in via the LCaos website at www.lcaos.eu/workshop2013/ . Once your abstract is accepted, you will need to either prepare an oral presentation or to develop a poster. Instructions will follow along with acceptance.
 
Location:
The LCAOS Workshop will be held in Hotel Scheidberg, St. Vallier Straße 1, 66798 Wallerfangen/Kerlingen, Germany.
 
Major Deadlines:
Abstract submission:            February 15, 2013
Letter of acceptance:            February 25 2012
Registration of lecturers:     March 15, 2013
Early registration:                 March 31, 2013
Standard registration:          May 15, 2013
Late poster registration will be possible until May 15, 2013 in case space is available.
 

ISOCS Short Course will be organized on June 14, 2013 also in Hotel Scheidberg, Wallerfangen, Germany.

 
The Short Course explores chemical sensors in breath analysis provides and covers knowledge on chemical sensors, data analysis and breath analysis for lung cancer detection as well as established medical practices for lung cancer detection.
The main objective is to give an overview of the available technologies and current research with a focus on practical applicability and real life problems.
The short course is ideal for medical scientists, clinicians and industrialists who want to get a head start on chemical sensors in breath analysis, and for researchers and engineers who want to use their technology in lung cancer breath analysis.
 
Organizers and lecturers are Prof. Santiago Marco from the University of Barcelona, Spain and Dr. Jan Mitrovics from JLM Innovation GmbH, Germany. Additional invited lecturers are Prof Hossam Haick from the Technion Institute of Technology, Israel and Dr. Nir Peled from the Sheba Medical Center, Israel.
 
Further information you can get by visiting: www.olfactionsociety.org/course/breath201 or by contacting Dr. Jan Mitrovics (jan.mitrovics@jlm-innovation.de )       .
 


LCaos Activities and Achievements

Two fruitful meetings and one successful project!

 
The board (technical) meeting of LCaos project that took place on the 25th of May 2012 in Nuremberg, Germany had a lot of similarities with the brainstorming meetings known from the high-tech world. The "technological-related" LCaos partners have met together for pushing forward the technological issues related to the development of the easy-to-use and easy-to-handle NA-NOSE device for instant diagnosis of the lung cancer.
 
The MPL group has reported on the synthesis and production of stand-alone silicon nanowires (Si NWs) by means of wet etching. Additionally, they reported on their studies to determine the kinetics and activation energy of the first stages of SiO2 growth in these Si NWs – an important observation that is needed for the functionalization of the Si NWs by the Technion team.
 
The Technion team has utilized the Si NWs produced by the MPL to fabricate molecule-terminated Si NW field effect transistors (Si NW FETs). In addition to these advances, the Technion team has reported on a new cost-effective (spray coating) method for the arrangement of Si NWs as an array of solid and flexible substrates. The method was patented and a publication describing the new technique was published in the prestigious ACS NANO journal.
 
Micronit has presented a preliminary prototype of the microfluidic system that host Si NW FETs produced by the Technion team, which, in turn, are based on the Si NWs produced in WP1. The devices were characterized electrically while being integrated in the microfluidic system. Some of the analysis was successful and the other ones showed a damage of the devices (most probably, during the shipment from Israel to the Netherlands). In addition, the team has presented a holder for the microfluidic system that enables integration with the electronic circuits developed by JLM.
 
JLM has presented a lab prototype consisting of several circuit board circuits that constitute a high resolution measurement system for SiNW FET sensors with large gate voltage range. The system is connected  via USB to a PC and provides means to control the sampling valves and measure complete I/V curves for the SiNW sensors in a fraction of the time needed with before.No external device analyzers are needed any longer- huge saving of costs at improved measurement capabilities and very good step toward miniaturizing the designated NA-NOSE. At the time of the meeting, the system was ready but still required more electrical examinations by the JLM team.
 
The UCM team has reported on an advance on the pattern recognition methods they develop for the purpose of analyzing the sensing signals produced by the NA-NOSE. The team has presented an adapted version of the Neural Network analysis that is suited for analyzing the Si NW FET data, both as a spectrum and as matric of physical parameters (e.g., voltage threshold, on-current, off-current, hole mobility, sub-threshold voltage, etc.). An initial Matlab software that analyze the Si NW FET parameters as a function of time was presented and discussed.
 
IONIMED has presented a new prototype of gas generator system. This gas generator is based on nebulizing an aqueous calibration solution through a nozzle into a heated environment. The parameters affecting the achieved analyte’s concentrations were presented and discussed. Initial tests have shown that the developed gas generator is able to produce analytes at concentration levels that range between a few ppb to a few hundreds of ppm. IONIMED has reported also on her interaction with the TAU team and the Technion team providing them with the PTR-MS and the breath sampling device needed for clinical tests of breath samples from patients with lung cancer and healthy people.
 
                                           
                                                                        LCaos project philosophy
 
On September 5-6, 2012, the 3rd General Assembly Meeting of LCaos project took place in Innsbruck, Austria – an event that was organized by our project partner IONIMED. The Opening Session welcomed the LCaos members as well as Prof. Anton Amann from Innsbruck Medical University – head of the Breath Research Institute of the Austrian Academy of Science. Following the welcome session, each WP leader presented the evolution of the project from the technical and scientific points of view, as well as the progress and results achieved from the beginning of the project April 2011 until September 2012. During the Closing Session, there were consultations on future project plans, on dissemination and administrative issues, on reporting and auditing processes, and on the preparation of the 1st EC Periodic Report. The meeting also included a tour of the IONIMED laboratories, led by Dr. Jens Herbig, and to the volatile biomarkers laboratories, led by Prof. Anton Amann. All the participants appreciated the meeting for the opportunity of a global view on the current progress and on our future plans.


 

LCaos Technical Developments

The Max-Planck Institute partner has produced, by bottom-up and top-down approaches, silicon nanowires (Si NWs) with an average diameter of 50-100 nm and different doping levels. All Si NWs were characterized by advanced imaging techniques, such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
 
The Technion partner has developed a spray-coating approach to allow aligned deposition of the Si NWs on a wide variety of solid and flexible devices. Additionally, the Technion partner has integrated both individual and Si NWs array with platforms of field effect transistors (FETs) and investigated cost-effective ways to use the resulting devices as sensors under real-world conditions. In this endeavor, the Technion team made a marked advance when they developed a molecularly-modified Si NW FET-based approach to detect polar and nonpolar gas analytes that are found in highly humidified samples.
 
In Liverpool University partners reported on a progress on several fronts. Using sampling techniques developed by the Tel-Aviv University partner and with analysis of Technion partner, they have embarked on in-vitro headspace VOC analysis for cell-lines that represent normal airway epithelial cells and the earliest precursors of lung cancer with defined genetic alterations. It has proved possible both to detect significant differences in the levels of defined VOCs by GC-MS and to discriminate between two closely related cell-lines with a single mutation. In order to understand the genetic basis of VOC discrimination of cancer subtypes, bioinformatics analysis is now tackling large datasets of genetic, expression and methylation data. These will be used to map tumour samples onto the molecular genealogy of lung cancer determined from these far larger datasets and to forecast the wider distribution of the VOC signatures measured in our own sample sets. In support of this, Liverpool University partner are also producing their own genetic datasets of tumours from patients with differing levels of pre-determined risk for lung cancer. Tumours with high or low epidemiological risk (LLP risk score) are being compared by Whole Genome Sequencing, microRNA profiling and DNA methylation analysis in order to define risk-associated (epi)genetic differences. This will provide a further parameter with which to test tumours with associated breath analysis and provide an insight into the molecular basis of VOC patterns associated with lung cancer risk.
 
In addition the in-vitro studies, the Liverpool University Partner they have reported on their continuation to collect breath samples from healthy volunteers who are part of one of the world’s largest population cohorts for the study of lung cancer risk. This population was used to generate the Liverpool Lung Project (LLP) risk model. LLP risk scores have been validated in independent datasets and are now being used to select subjects for the UK CT screening trial (UKLS). Within LCAOS, LLP risk score together with other epidemiological data will be analysed against breath VOC signatures in order to integrate breath analysis in the early detection setting.
 
Tel Aviv University has received the PTR-MS on August 2012. The PTR-MS was installed by Ionimed representatives and the Israeli team received an instruction and lecture regarding using the PTR-MS. They started to perform in-vitro assays in order to distinguish between the VOC of different kinds of lung cancer cells and also to find changes in VOC's profile after metabolic drug modification. They try to standardize the experiments and to reduce the background to minimum. They also collected breath samples from lung cancer patients at different stages of the diseases. They collect three bags at each time, two of them are absorbed on Tenax reusable tubes and sent to analysis at the Technion (artificial nose and GC-MS). The third bag is sampled on the PTR-MS. In the future they intend to compare the results from the three different devices.
                                                  
                  Sampling with PTR-MS at our clinic                  TAU Team's trip to "Ayalon Institute Museum" in Rehovot
 
 
The University Complutense of Madrid has designed, optimized and tested a competitive unsupervised artificial neural network for two types of sensors as well as a new algorithm based on self-organizing maps/chaotic parameters to extract hidden information in huge databases. These chaotic parameters can be calculated following a really simple equation, and can even be done using a basic calculator. Part of their work was to classify the volatile compounds and to estimate their concentrations by Si NW FET and Neural networks. In order to classify volatile compounds and determine their concentrations, combinations of different types of silicon nanowire FET (Si NW FET) sensors and nonlinear algorithms have been tested. Methods based on Si NW FET sensors and supervised artificial neural networks (NNs) have been used to classify polar and non-polar volatile compounds. While validating this tool, no misclassifications were found. Similar NN algorithms and several types of Si NW FET sensors have been used to determine the concentration of the aforementioned compounds. Although in every case the mean prediction error values were less than 3%, when the most suitable Si NW FET sensor was used, the mean prediction error decreased to less than 1.50 %. In the light of these results, the combination of Si NW FETs and supervised artificial neural networks is a suitable tool to classify compounds as polar and non-polar, as well as to estimate their concentrations.
 
                                
 
The Micronit Partner has fabricated microfluidic exposure cells made from glass and mounted functionalized silicon nanowire FETs which were produced at the Technion. This is the first time that the nanowire FETs are integrated with a microfluidic system and tests are currently underway to assess the performance.
                                                         
 
 
 
Partner JLM Innovation presented the progress on the SiNW measurement platform. The system has been considereable improved from the previous version and software integration is ongoing. Two different analog frontends provide means to measure either 20 SiNW FET sensors or 20 resistive NP sensors.
                                           
 
The project partner Ionimed developed an instrument to produce artificial breath for sensor training and sensor calibration. A first prototype of such a Liquid Calibration Unit was further improved into a “ready-to-market” product, which is capable to efficiently evaporize mixtures of breath relevant chemicals to produce a gas of a stable and well defined concentrations representative for human breath. This LCU system was successfully coupled to sensor arrays. First tests clearly showed sensor responses to different concentrations produced by the LCU. The results of these initial experiments will trigger further improvements, such as a wider range of concentrations. A Proton-Transfer-Reaction Mass-Spectrometer, capable of quantitatively analyzing a large variety of volatile organic compounds (VOC) at trace concentrations, was implemented into the breath analysis lab of the Tel Aviv University. With the support of Ionimed, the researchers use this instrument for the validation and improvement of their sampling procedures, for VOC analysis of the head space of cancer cell lines and for breath gas analysis in real time, which is performed in parallel to the breath analysis by GC-MS and NA-NOSE at Technion.

 


 
 
 

LCaos Events, Publications and Awards

Here is a selection of some relevant workshops and conferences attended by various LCaos teams during the last period:

  • Prof. Hossam Haick made a presentation to The Lung Cancer Center, University of Colorado Cancer Center, Aurora, Colorado, USA, 19 January 2012.
  • Prof. Hossam Haick made a presentation to Fresenius Medical Care, Fresenius Headquarters, Bad Homburg v.d.H. Germany, 29 February 2012.
  • Prof. Hossam Haick made a presentation to The 46th Annual Conference of the Israel Society for Clinical Laboratory Sciences (ISCLS), Maccabiah Hotel, Kfar Maccabiah, Israel, 20 March 2012.
  • Prof. Hossam Haick made a presentation to The Partnership and Growth 2012 Prime Minister's Conference, Dan Carmel Hotel, Haifa, Israel, 20 March 2012.
  • Prof. Hossam Haick made a presentation to The Ministry of Security Annual Conference on Sensors for Dangerous Material, Tel-Aviv University, Tel-Aviv, Israel, 22 March 2012.
  • Prof. Hossam Haick made a presentation to The Israel-China Bilateral Conference on Nanotechnology, Dan Panorama Hotel, Tel-Aviv, Israel, 28-29 March 2012.
  • Dr. Jan Mitrovics, Mr. Sergi Udina, Prof. Hossam Haick and Prof. Jose Torrecilla attended and made presentations to IMCS 2012 - The 14th International Meeting on Chemical Sensors, Nuremberg, Germany, 20-23. May 2012.
  • Dr. Jan Mitrovics and Mr. Sergi Udina made presentations to SENSOR+TEST - The Measurement Fair - Presentation of the LCaos project at the booth of JLM Innovation GmbH on the trade show Sensor+Test 2012, Nuremberg, Germany, 22-24 May 2012.
  • Prof. Hossam Haick made a presentation to Center for Nanoscience and Nanotechnology, Hebrew University of Jerusalem, Jerusalem, Israel, 3 June 2012.
  • Prof. Hossam Haick made a presentation to The Annual Conference of Ministry of Health, ISROTEL-Princess Hotel, Eilat, Israel, 04 June 2012.
  • Prof. Hossam Haick made a presentation to The Annual Conference of the Israeli Occupational Medicine Association, Soker Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 11 June 2012.
  • Prof. Jose Torrecilla made a presentation to 6th Annual International Conference on Mathematics & Statistics, Athens, Greece, 11-14 June 2012.
  • Prof. Hossam Haick made a presentation to The 9th National MUTAV Conference, The department for Science Education, Technion – Israel Institute of Technology, Haifa, Israel, 27 June 2012.
  • Prof. Jose Torrecilla made a presentation to the 20th International Congress of Chemical and Process Engineering, Prague, Czech Republic, 25-29 August 2012.
  • Prof. Hossam Haick made a presentation to 1st Polish – Israeli Seminar on “Biomedical Engineering Approaches in Chronic Diseases, The International Center of Biocybernetics, Warsaw, Poland, 3-4 September 2012

Presentations given by different LCAOS members:

  • Prof. Hossam Haick made a presentation to Hôspital Marie Lannelongue, Le Plessis-Robinson, France, 6 May 2011
  • Prof. Hossam Haick made a presentation to The Schulich Faculty of Chemistry, Technion – IIT, Haifa, Israel, 10 May 2011
  • Prof. Hossam Haick made a presentation to The Faculty of Natural Science, Bethlehem University, West Bank, 11 May 2011
  • Prof. Hossam Haick made a presentation to The Biology Department of Technion, Technion – IIT, Haifa, Israel, 7 November 2011
  • Prof. Hossam Haick made a presentation to The Engineers Association, Pais Auditorium, Ramat-Gan, Israel, 16 November 2011
  • Prof. Hossam Haick made a presentation to BEZEQ EXPO, Exhibition Halls, Tel-Aviv, Israel, 20 December 2011
  • Prof. Hossam Haick made a presentation to The Department of Biochemistry and Molecular Biology, the Hebrew University Medical School, Ein-Karem, Jerusalem, Israel, 22 March 2012
  • Prof. Hossam Haick made a presentation to The ORT Biotech Workshop, Netanya Harmelin ORT College, Netanya, Israel, 27 March 2012
  • Prof. Hossam Haick made a presentation to The Schulich Faculty of Chemistry, Technion, IIT, Haifa, Israel, 10 May 2012
  • Prof. Hossam Haick made a presentation to The Faculty of Natural Science, Bethlehem University, West Bank, 11 May 2012
  • Prof. Jose Torrecilla made a presentation to Combination of self-organizing map and chaotic parameters for classifying anomalous digital signals Athens, Greece, 13 June 2012

 

Workshops attended by LCAOS team members:

  • Prof. Hossam Haick made a presentation to The Bnai-Zion Center Workshop, Bnai-Zion Medical Center, Haifa, Israel, 31 May 2011
  • Prof. Hossam Haick made a presentation to IASLC EDPC - Lung Cancer Biomarkers Workshop WCLC 2011, RAI Convention Centre, Amsterdam, the Netherlands, 1-2 July 2011
  • Prof. Hossam Haick made a presentation to Mérieux Research Workshop, Centre de Conférences Les Pensières, VEYRIER DU LAC, France, 24-25 October 2011
  • Prof. Hossam Haick made a presentation to PhD Student training on PTRMS at IONIMED June 2012, Austria, Innsbruck, Austria, 17-23 June 2012
  • Prof. Hossam Haick made a presentation to Technion-Cornell Healthier Life Workshop, Weill Cornell Medical College, New York City, New York, US, 26-27 July 2012

 
 

Relevant publications issued by LCaos teams:

  • Peled, N., Ionescu, R., Nol P., Barash, O., McCollum, M., VerCauteren, K., Koslow, M., Stahl, R., Rhyan, J., Haick, H., Detection of Volatile Organic Compounds in Cattle Naturally Infected with Mycobacterium bovis, Sensors & Actuators: B. Chemical, 171-172:588-594, 2012
  • Peled, N., Barash, O., Tisch, U., Bunn, P. A. Jr. R., Hirsch, F. R., Haick, H., Classification of the Lung Cancer Histology by Gold Nanoparticle Sensors, NanoMedicine, 8(5): 580-589, 2012
  • Peled, N., Hakim, M., Bunn, P. A. Jr. R., Miller, Y. E., Kennedy, T. C, Mattei, J., Mitchell, J. D, Weyant, M. J., Hirsch, F. R., Haick, H., Non-Invasive Breath Analysis for Solitary Pulmonary Nodules, J. Thoracic Oncology, 7:1528-1533, 2012
  • Hakim, M., Broza, Y. Y., Barash, O., Peled, N., Phillips, M., Amann, A., Haick, H., Formation of volatile organic compounds associated with lung cancer and possible biochemical pathways, Chemical Reviews, September 2012 (Peer Review)
  • Tisch, U., Peled, N., Billan, S., Phillip, M., Ilouze, M., Haick, H., Volatile Biomarkers in the Exhaled Breath for the Early Detection and Screening of Lung Cancer, Current Medical Literature – Lung Cancer 5(4):107-17, 2012
  • Wang, B., Stelzner, T., Dirawi, R.; Assad, O., Christiansen, S., Haick, H., Scaling Properties of Transistor Channels That Use Aligned Arrays of Si Nanowires, SMALL, 2012
  • Paska, Y., Haick, H., Interactive Effect of Hysteresis and Surface Chemistry on Gated Silicon Nanowire Gas Sensors, ACS Appl. Mater. Interf., 04.05.2012
  • Field, J. K., Smith, R. A., Aberle, D. R., Oudkerk, M., Baldwin, D. R., Yankelevitz, D., Pedersen, J. H., Swanson, S. J., Travis, W. D., Wisbuba, I. I., Noguchi, M., Mulshine, J. L., Haick, H., IASLC CT Screening Workshop 2011 Participants. International Association for the Study of Lung Cancer Computed Tomography, Screening Workshop 2011 Report, J. Thoracic Oncol. 7(1): 10-19, 2012
  • Bashouti, M. Y., Sardashti, K., Ristein, J., Christiansen, S. H., Early stages of oxide growth in H-terminated silicon nanowires: determination of kinetic behavior and activation energy, Physical Chemistry Chemical Physics,14(34):11877-81, 2012
  • Tisch, U., Haick, H., Arrays of Nanomaterial-based Sensors for Breath Testing, Volatile Biomarkers, 115-127, Anton Amann and David Smith (Eds.), 2012
  • Miekisch, W., Herbig, J., Schubert, J. K., Data interpretation in breath biomarker research: pitfalls and directions, J. Breath Research, IOP Publishing, J. Breath Res. 6, 036007, 10pp, 2012
  • Paska, Y., Stelzner, T., Christiansen, S., Haick, H., Enhanced Sensing of Nonpolar Volatile Organic Compounds by Silicon Nanowire Field Effect Transistors, ACS NANO, 5(7) 5620-5626, 2011
  • Haick, H., A Nanosensor Array for Detecting Volatile Biomarkers of Cancer, AIP Conf. Proc., 1362:15-16, 2011
  • Haick, H., Early Detection and Screening of Lung Cancer via Volatile Biomarkers. Proc. WCLC14, J. Thorac. Oncol., 6(6):20-25, 2011
  • Torrecilla, J. S., García, J., García, S., Matute, G., Rodríguez, F., Modelling of hydrocarbon solubility in isomeric ionic liquids using mathematical regressions, Separation Science & Technology, 47 (2012), 392-398, 2011

 

List of Exploitable Foregrounds developed via LCAOS project collaboration:

 

No. Date Title Exploitable Foreground (description) Exploitable product(s) or measure(s) Sector(s) of application Timetable for commercial use Patents or other IPR exploitations (licenses) Owner(s)
1 2012-09-29 Microfluidic exposure cell with sensor chips A microfluidic exposure cell has been developed onto which a number of sensor chips are assembled using a flup-chip bonding approach. The exposure cell directs fluid from the inlet to the multitude of sensors. Electrical traces on the exposure cell provide a convenient means for making electrical contact between a readout instrument and the sensor chips. Microfluidic exposure cell with sensor chips Microtechnology, chemical sensing Functional characterization needs to be completed first The exposure cell concept can be exploited also for other sensing applications MMBV
2 2012-06-27 FET characterization platform A prototype measurement platform has been developed that can measure arrays of FET based sensors using a large range of gate voltage from -60 to +60V. Theese high voltages are typical requirements for nanowire based sensors.  
 
Measurement instrumentation for nanotechnology Redesign and certifications are required The measurement platform can be adopted to a range of application by exchanging the analog frontend, firmware and software JLM
3 2012-08-01 Liquid Calibration Unit A Liquid Calibration Unit (LCU) has been developed, which can be used to produce precise trace gas concentrations of organic and inorganic compounds in gas. The gas matrix is humid and the admixing of CO2 allows simulating conditions found in breath gas. This device has been developed for calibration and training of sensors within LCAOS. LCU - Liquid Calibration Unit Analytics, Trace gas calibration Product launch end 2012 The LCU will be marketed for versatile calibration of any kind of trace gas analyzers. ION
4 2012-08-01 Active Liquid Flow Controller In the frame of the development of the Liquid Calibration Unit, the need for a precise flow controller for liquids with low internal dead space volume arose. This lead to the development of the Ionimed active Liqud Flow controller, which has a dead-space volume of < 100 µl can control flows in the range of 0, 1, … 50 µl, with an active, i.e. self-priming, inlet. aLFC - active Liquid Flow Controller Microfluidics Product launch 2013 The aLFC is a component of the LCU but will be marketet as a seperate OEM product. ION

 


 

LCaos Exchanges and Position Openings

We are pleased to announce an open position on the team of Dr. Nir Peled (Tel Aviv University):
Position: M. Sc. student.
Responsibilities: Analyzing the PTR-MS results, comparing to molecules libraries, and identification of the metabolic pathways that the VOCs have originated from.
Education: M.Sc. student in Organic chemistry field.